Fatal anaphylaxis in systemic mastocytosis.

Fatal anaphylaxis in systemic mastocytosis.

A 42-year-old woman died after an episode of anaphylaxis associated with a raised serum histamine level. A diagnosis of systemic mastocytosis was established, with lymphadenopathy and hepatosplenomegaly, not associated with the usually pre-existing skin lesions of urticaria pigmentosa.

Anaphylaxis in Mastocytosis*

M.C. Castells (ed.), Anaphylaxis and Hypersensitivity Reactions, DOI 10.1007/978-1-60327-951-2_16, © Springer Science+Business Media, LLC 2011 Abstract An increase in anaphylaxis has been reported in mastocytosis, with a predominance of males. Recurrent idiopathic anaphylaxis and either hymenoptera-venom or drug-induced anaphylaxis are the most frequent types of anaphylaxis, no correlation bein...

Omalizumab induced remission of idiopathic anaphylaxis in a patient suffering from indolent systemic mastocytosis.

Tryptase levels as an indicator of mast-cell activation in systemic anaphylaxis and mastocytosis.

Better methods are needed to assess mast-cell activation in vivo and to distinguish the activation of mast cells from that of basophils. Tryptase, a neutral protease selectively concentrated in the secretory granules of human mast cells (but not basophils), is released by mast cells together with histamine and serves as a marker of mast-cell activation. In 17 patients with systemic mastocytosis...

Fatal asthma or anaphylaxis?

The incidence of anaphylaxis is under-reported. Children with asthma are frequently atopic and prone to allergic reactions. Parents and clinicians may attribute wheeze of rapid onset to acute severe asthma, rather than recognising an anaphylactic event. Two cases of fatal anaphylaxis are reported who were initially diagnosed as acute severe asthma, and responded poorly to bronchodilator treatme...